Without a doubt, nausea and vomiting are common side effects of pregnancy. Hyperemesis gravidarum is a rare and severe complication of pregnancy that requires appropriate diagnosis and management to improve the patient’s quality of life and provide best possible maternal and neonatal outcomes. Physicians must appreciate the magnitude of the condition given its widespread implications – economic costs, decreased quality of life, maternal psychological effects, and risks to mother and fetus. Common maternal complications include dehydration, weight loss, and nutrient deficiencies. Current strategies include dietary modification, antiemetic therapy, and in certain situations, alimentary support. Use caution when prescribing phenothiazines because dystonia and extrapyramidal symptoms can occur with prolonged use and high dose. Future strategies should include more randomized controlled trials therapies that are safe for both mother and fetus, and effective treatment to prevent hospitalization and offer alternatives for nutritional support.Read More