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Patient Safety

Patient safety is a fundamental principle of health care. Understanding the causes of medical error and strategies to reduce harm is simple compared with the complexity of clinical practice. Communication breakdown remains a leading contributor to adverse events in the United States. Every point in the process of care-giving contains a certain degree of inherent unsafety. A number of countries have published studies showing that significant numbers of patients are harmed during health care, either resulting in permanent injury, increased length of stay in health care facilities, or even death. Clear policies, organizational leadership capacity, data to drive safety improvements, skilled health care professionals and effective involvement of patients in their care, are all needed to ensure sustainable and significant improvements in the safety of health care. The purpose of this document is to discuss strategic pathways to accelerate future improvement in patient safety. It includes fundamental changes in health care education, patient engagement, transparency, care coordination, and improving health care providers’ morale. Transforming groups of individual experts into expert teams is central to this cultural transformation. This document aims to address the weakness in health systems that lead to medication errors and severe harm that results. It lays out ways to improve the way medicines are prescribed, distributed, and increase awareness among patients about the risks associated with the improper use of medications. Both health workers and patients can make mistakes that result in severe harm, such as prescribing, ordering, dispensing, preparing, administrating or consuming the wrong medication or the wrong dose at the wrong time. But all medication errors are potentially avoidable. Preventing errors and the harm that results requires putting systems and procedures in place to ensure the right patient receives the right medication at the right dose at the right time. Although much progress has been made, there is still much work to be done to reduce iatrogenic harm. Key to future improvement is engaged clinical and organizational leadership that must drive a shift in culture and help transform individual experts into expert teams.

Normal Values in Pregnancy

The physiologic, biochemical, and anatomic changes that occur during pregnancy are extensive and may be systemic or local. However, most systems return to pre-pregnancy status between the time of delivery and 6 weeks postpartum. Major adaptation in maternal anatomy, physiology, and metabolism are required for a successful pregnancy. Hormonal changes, initiated before conception, significantly alter maternal physiology, and persist through both pregnancy and initial postpartum period. A full understanding of physiologic changes is necessary to differentiate between normal alterations and those that are abnormal. This document describes maternal adaptations in pregnancy. An understanding of the normal physiologic changes and values induced by pregnancy is essential in understanding coincidental disease processes. Many laboratory values are dramatically altered from non-pregnant values. We hope this provides a valuable tool to manage your patients effectively.

Hormonal Contraception: The Challenges Ahead

For many women, safe and effective hormonal contraception is a mainstay of successful pregnancy planning and a source of important non-contraceptive benefits. Several new formulations and delivery systems for hormonal contraception offer long-term, non-daily, reversible alternatives to daily oral regimes. The availability of these new products and the continued viability of the older hormonal and non-hormonal methods allow physicians to individualize therapy according to patients’ needs and preferences. The purpose of this document to summarize both technical and programmatic aspects of hormonal contraceptive use. The methods of hormonal contraception are discussed in order of efficacy from highest to lowest. We hope to help healthcare providers in clinical decision making regarding hormonal contraception use in their population and to identify and discourage the unnecessary practices, tests and procedures. Facilitating contraceptive use and reducing barriers to contraceptive provision are also discussed. The public is often aware of the risks of hormonal contraceptives that are all-too-often described by sensational reports in media; these drugs remain among the most studied products on the market, helping millions of women worldwide to safely and effectively prevent unintended or unplanned pregnancy.

Uterine Cancer: A Modern Approach to Surgical Management

This review discusses the current understanding of endometrial cancer and to provide guidelines for management that have been validated by appropriately conducted outcome-based research when available. Additional guidelines on the basis of consensus and expert opinion also are presented. A thorough understanding of the epidemiology, pathophysiology, and diagnostic and management strategies for this type of cancer allows the gynecologists to identify women at increased risk, contribute toward risk reduction, and facilitate early diagnosis. Sentinel lymph node (SLN) mapping is based on the concept that lymph node metastasis is the result of an orderly process; that is, lymph drains in a specific pattern away from the tumor, and therefore, if the SLN, or first node, is negative for metastasis, then the nodes after the SLN, should be negative. This approach can help patients avoid the side effects associated with a complete lymphadenectomy, although disease must be thoroughly staged for accurate prognosis and determination of appropriate treatment approach. Surgeon experience, adherence to an SLN algorithm, and the use of pathologic “ultra-staging” are key factors for successful SLN mapping.

Medical Liability: Coping With Litigation Stress

The stress resulting from a medical liability case can have a negative effect on physician’s personal and professional life, and their ability to defend themselves against the charge. The purpose of this document is to promote mental wellbeing of healthcare providers by the provision of productive and healthy workplaces. Wellness goes beyond merely the absence of distress and includes being challenged, thriving, and achieving success in various aspects of personal and professional life. When physicians are unwell, the performance of healthcare systems can be suboptimum. Physician wellness might not only benefit the individual physician, it could also be vital to the delivery of high-quality health care. This review discusses the work stresses faced by physicians, the barriers to attending to wellness, and the consequences of unwell physicians to the individual and to healthcare systems. There are many programs in the USA, Canada and UK that are designed to improve physician’s wellness by recognition of potential health problems and by the provision of education and support (e.g. from basics such as getting enough food at work, sleeping properly, and to how to deal with adverse events, complaints, and litigation). The endpoint is better care for patients and improved system outcomes. Individual physician wellness is a valid indicator for organizational health. Healthy physicians mean healthier patients, safer care, and a more sustainable workforce.

Ectopic Pregnancy

Ectopic pregnancy is a condition in which an early embryo (fertilized egg) implants outside the normal site for implantation (uterus). The purpose of the document is to diagnose early, and to understand conservative medical and surgical treatments that are now widely available for ectopic pregnancies. Methotrexate, a folinic acid antagonist, has been used to treat patients with small unruptured tubal pregnancies. Evidence, including risks benefits, about methotrexate as an alternative treatment for selected ectopic pregnancy is also discussed. Early detection may make it possible for some patients to receive medical therapy instead of surgery.

Human Papillomavirus (HPV) Vaccines: A Reproductive Health Perspective

New vaccines designed to prevent human papillomavirus (HPV) infection have the potential to reduce the incidence of serious illness and death worldwide among women, substantially reduce emotional suffering associated with abnormal Papanicolaou (Pap) test results and the diagnosis of cervical cancer, and save significant healthcare dollars. HPV vaccines are expected to significantly reduce HPV-associated morbidity and mortality. The purpose of this article is to review some of the barriers to HPV vaccine acceptance, with a particular focus on factors relevant to female patients, parents, and healthcare providers. It also explores avenues for service delivery of HPV vaccines and critical information gap that must be bridged in order to inform future sexual and reproductive health programming. It proposes the role that the sexual reproductive health community, together with immunization and cancer control programs, could have in supporting the introduction of HPV vaccines within the context of current health systems. The benefits of HPV vaccine may not be fully realized until the vaccine is accepted by patients, parents, and healthcare practitioners. Furthermore, there may be unique issues related to the acceptance of a vaccine designed to prevent a sexually transmitted infection that is poorly understood by many women.

Medical Liability: Tort Reform

The greatest ongoing challenge for health care reform in the United States is to provide better health care for less money. Both aspirations are possible, but only if the nation is willing to overhaul the unreliable system of medical justice. Containing costs requires changing the rules for all participants. A range of malpractice reform proposals have been suggested as part of the national debate, and it is useful to examine them and identify the advantages of each. All of these reforms have significant merit, but special health courts are by far the most important in reducing defensive medicine. Perhaps the most important reason for adopting administrative compensation models for adverse medical outcomes is the effect on patient safety and quality of care. Adverse outcomes, preventable or otherwise, are an uncomfortable reality of medical care. Disclosure and discussion of adverse events in health care is desired by patients and championed by safety experts and policy makers.

Current Ovarian Cancer Management

Epithelial ovarian cancer is the second most common gynecologic malignancy, but is the leading cause of death from gynecologic cancer in the United States. In this discussion four updates are selected based on recent important updates in the guidelines and on debate among the experts about recent clinical trials. The topics include:

1) intraperitoneal (IP) chemotherapy,
2) CA-125 monitoring for ovarian cancer recurrence,
3) surveillance recommendations for less common ovarian histopathologies, and
4) recent changes in therapy for recurrent epithelial ovarian cancer.

During primary surgery for advanced stage epithelial ovarian cancer all attempts should be made to achieve complete cytoreduction. When this is not achievable the surgical goal should be optimal (<1cm) residual disease. All women undergoing surgery for ovarian cancer should be counseled about the clinical benefit associated with combined intravenous (IV) and intraperitoneal (IP) chemotherapy administration prior to surgery. Surgical cytoreduction (debulking) is recommended as initial treatment for many women with ovarian cancer, even those with metastatic disease. After surgical debulking, adjuvant systemic therapy (e.g. taxane/platinum) is recommended for many patients. Several different systemic regimens are recommended. Primary adjuvant therapy regimens include intravenous (IV) with (or without) intraperitoneal (IP) options. All of the regimens may be used for epithelial ovarian, primary peritoneal, and fallopian tube cancers.

Female Genital Cutting: Impact on Maternal and Neonatal Outcomes

Female genital cutting (FGC) is the collective name given to traditional practices that involve partial or total cutting away of the female external genitalia whether for cultural or other non-therapeutic reasons. These beliefs and practices can damage the health of both mother and child in various ways. FGC, for instance, leads to scarification and later complications in childbirth. Female genital cutting/mutilation has no known health benefits. On the contrary, it is known to be harmful to girls and women in many ways. First and foremost, it is painful and traumatic. The removal of or damage to healthy, normal genital tissue interferes with the natural functioning of the body and causes several immediate and long-term health consequences. Babies born to women who have undergone female genital mutilation suffer a higher rate of neonatal death compared with babies born to women who have not undergone the procedure. Girls have the right to grow to womanhood without harm to their bodies. We know what has to be done to abandon this harmful practice, strong support from governments encouraging communities and individuals to make the healthiest choices possible for girls will save lives and greatly benefit families and communities.